MEA1

Across TCGA patient cohorts, MEA1 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEA1-associated genes across cancer lineages are OR5B2, RNA5SP536, and LINC01541. Each is linked with MEA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEA1-to-partner and partner-to-MEA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5B2 grouped by MEA1-low versus MEA1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEA1→partner) and Y-score (partner→MEA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR5B2 →	+0.149	+4.766	.002	.003	3	2
BRCA	RNA5SP536 →	+0.344	+4.610	<.001	.008	3	1
BRCA	LINC01541 →	+0.132	+4.232	<.001	.009	3	1
UCEC	RN7SL478P →	+0.522	+3.354	<.001	.007	3	1
BRCA	RNU1-24P →	+0.328	+5.009	.006	.002	3	1
BRCA	VPS26CP1 →	+0.099	+5.442	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

OR5B2 by MEA1 expression — BRCA

Explore this box plot interactively →