MEA1

Across TCGA pan-cancer cohorts, MEA1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MEA1 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher MEA1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MEA1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and OV show a favorable association.

KICH, ACC, and MESO are the cancer types where MEA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.667	0.976	<.001	92	view →
ACC	DFS	Median	All	0.242	0.649	<.001	74	view →
MESO	OS	Quartile	All	0.449	0.679	.003	47	view →
SARC	DFS	Tertile	All	0.355	0.622	<.001	43	view →
LAML	DFS	Quartile	All	0.331	0.717	<.001	40	view →
LUSC	OS	Tertile	All	0.719	0.589	.001	35	view →
SKCM	OS	Tertile	II,III,IV	0.747	0.908	.001	35	view →
OV	OS	Quartile	IV	0.743	0.342	.001	26	view →
LIHC	OS	Quartile	All	0.702	0.871	.001	21	view →
THYM	OS	Quartile	All	1.000	0.622	.005	19	view →
CHOL	DFS	Tertile	All	0.124	0.709	.002	18	view →
COAD	DFS	Tertile	II,III,IV	0.692	0.819	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MEA1–KICH (DFS)

Open the KICH breakdown →