MDH1

Across TCGA patient cohorts, MDH1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,509 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MDH1-associated proteins across cancer lineages are MCM2, UBE2T, and MCM2_S139. Each is linked with MDH1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MDH1-to-partner and partner-to-MDH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDH1 versus MCM2 in BRCA, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH1→partner) and Y-score (partner→MDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MCM2 →	+0.587	+0.402	<.001	<.001	3	7
COAD	UBE2T →	+0.803	+0.803	<.001	<.001	3	6
LSCC	MCM2_S139 →	+0.751	+0.625	<.001	<.001	3	6
LSCC	MCM3 →	+0.642	+0.449	<.001	<.001	3	6
LSCC	MCM4 →	+0.621	+0.444	<.001	<.001	3	6
LSCC	MCM5 →	+0.636	+0.436	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,509 associations by consensus.

MDH1 vs MCM2 — BRCA

Explore this scatter interactively →