MDH1

Across TCGA pan-cancer cohorts, MDH1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MDH1 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MDH1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MDH1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SCLC show a favorable association.

LUAD, LUSC, and UVM are the cancer types where MDH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.234	0.496	.001	83	view →
LUSC	OS	Tertile	All	0.759	0.575	<.001	74	view →
UVM	DFS	Quartile	All	0.331	0.882	<.001	74	view →
LIHC	OS	Tertile	II,III,IV	0.389	0.725	<.001	49	view →
KICH	DFS	Tertile	II,III,IV	0.592	1.000	.005	48	view →
ESCA	DFS	Tertile	III,IV	0.218	0.542	.002	43	view →
SCLC	DFS	Quartile	All	1.000	0.390	.012	31	view →
ACC	OS	Median	IV	0.308	0.733	.004	26	view →
BLCA	OS	Median	II,III,IV	0.660	0.754	.009	23	view →
STAD	DFS	Median	IV	0.207	0.612	.013	19	view →
UCEC	DFS	Quartile	All	0.786	0.886	.009	16	view →
READ	DFS	Quartile	All	0.951	0.643	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MDH1–LUAD (DFS)

Open the LUAD breakdown →