MDH1

Across TCGA pan-cancer cohorts, MDH1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MDH1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MDH1 RNA is repressed in tumor relative to normal tissue. In most cancer types MDH1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, LIHC, and BRCA are the cancer types where MDH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MDH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.702	<.001	9	view →
LIHC	Female	II,III,IV	+0.981	<.001	8	view →
BRCA	All	All	−0.328	<.001	8	view →
KICH	Female	II,III,IV	−1.175	<.001	7	view →
LUSC	Female	All	+0.999	<.001	7	view →
COAD	Male	All	−0.376	.001	6	view →
CHOL	All	All	+0.992	<.001	5	view →
READ	All	All	−0.459	.006	3	view →
PRAD	All	All	−0.228	.034	2	view →
LUAD	All	All	+0.167	.016	2	view →
KIRP	Male	All	−0.375	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MDH1–KIRC

Open the KIRC breakdown →