MDH1

Across TCGA patient cohorts, MDH1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,996 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MDH1-associated genes across cancer lineages are ABCA8, CBX7, and ASPA. Each is linked with MDH1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MDH1-to-partner and partner-to-MDH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDH1 versus ABCA8 in UCEC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH1→partner) and Y-score (partner→MDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABCA8 →	+1.153	+0.157	<.001	.002	3	7
UCEC	CBX7 →	+0.739	+0.174	<.001	<.001	3	6
GBM	ASPA →	+0.860	+0.290	<.001	<.001	3	6
BRCA	FHL5 →	+0.949	+0.261	<.001	.001	3	6
COAD	ISCU →	+0.392	+0.248	<.001	<.001	3	6
LUAD	SCN7A →	+1.104	+0.148	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,996 associations by consensus.

MDH1 vs ABCA8 — UCEC

Explore this scatter interactively →