MDH1

Across TCGA patient cohorts, MDH1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDH1-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and EGFR_pY1173. Each is linked with MDH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDH1-to-partner and partner-to-MDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MDH1-low versus MDH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH1→partner) and Y-score (partner→MDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.156	+2.999	.005	.035	3	2
UCEC	EGFR_pY1068 →	-0.225	-2.584	.022	.010	3	1
UCEC	EGFR_pY1173 →	+0.106	+3.169	<.001	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-2.489	.005	.002	3	1
UCEC	Ku80 →	+0.332	+3.183	<.001	<.001	3	1
UCEC	p27_pT198 →	+0.089	+2.321	.033	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

C-Raf by MDH1 expression — UCEC

Explore this box plot interactively →