MDH1

Across TCGA cell cohorts, MDH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,313 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MDH1-associated GO terms across cancer lineages are Cellular response to molecule of bacterial origin, Cellular response to lipopolysaccharide, and Regulation of DNA damage checkpoint. Each is linked with MDH1 in more than 13 cancer types. Because this analysis shows association rather than direction, both MDH1-to-partner and partner-to-MDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to molecule of bacterial origin grouped by MDH1-low versus MDH1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH1→partner) and Y-score (partner→MDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cellular response to molecule of bacterial origin →	-0.067	-0.653	<.001	.002	3	14
UPPER_AERODIGESTIVE_TRACT	Cellular response to lipopolysaccharide →	-0.073	-0.586	<.001	.007	3	14
OVARY	Regulation of DNA damage checkpoint →	+0.100	+0.505	<.001	<.001	3	13
PANCREAS	Cellular response to biotic stimulus →	-0.066	-0.569	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein localization to chromosome, centromeric region →	+0.138	+0.953	<.001	.001	3	12
OESOPHAGUS	Immunoglobulin heavy chain V-D-J recombination →	+0.177	+0.659	.008	.007	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,313 associations by consensus.

Cellular response to molecule of bacterial origin by MDH1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →