MCUB

Across TCGA patient cohorts, MCUB mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCUB-associated genes across cancer lineages are PPIAP83, LINC00328-2P, and ATF4P3. Each is linked with MCUB in more than 1 cancer types. Because this analysis shows association rather than direction, both MCUB-to-partner and partner-to-MCUB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAP83 grouped by MCUB-low versus MCUB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCUB→partner) and Y-score (partner→MCUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PPIAP83 →	+0.246	+3.003	<.001	.004	3	2
UCEC	LINC00328-2P →	+0.097	+3.113	<.001	.006	3	2
UCEC	ATF4P3 →	+0.307	+2.928	.007	.001	3	2
UCEC	GAPDHP1 →	+1.005	+2.254	.005	.006	3	2
UCEC	MIR4444-2 →	+0.369	+2.289	<.001	.004	3	1
UCEC	RPIAP1 →	+0.069	+2.260	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

PPIAP83 by MCUB expression — COAD

Explore this box plot interactively →