MCUB

Across TCGA pan-cancer cohorts, MCUB RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MCUB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MCUB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MCUB is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where MCUB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MCUB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.065	<.001	12	view →
KIRC	Male	IV	+1.524	<.001	11	view →
THCA	Male	III,IV	+1.574	<.001	8	view →
KIRP	Male	All	+1.170	<.001	8	view →
STAD	All	II,III,IV	+0.765	.001	7	view →
COAD	All	II,III,IV	+0.656	.001	7	view →
BRCA	All	II,III,IV	+0.560	<.001	6	view →
LIHC	Female	All	+0.816	.001	3	view →
CHOL	All	All	+1.896	.001	2	view →
ESCA	All	All	+1.395	.003	2	view →
UCEC	All	All	−0.663	.022	2	view →
BLCA	All	All	+0.538	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MCUB–HNSC

Open the HNSC breakdown →