MCU

Across TCGA patient cohorts, MCU protein abundance is significantly associated with the RNA expression of many other genes, with 10,881 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCU-associated genes across cancer lineages are HEATR1, FAM20B, and ASH1L. Each is linked with MCU in more than 4 cancer types. Because this analysis shows association rather than direction, both MCU-to-partner and partner-to-MCU results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCU versus HEATR1 in BRCA, with a Pearson correlation of -0.22.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCU→partner) and Y-score (partner→MCU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HEATR1 →	-0.531	-0.251	.002	.006	3	5
LSCC	FAM20B →	-0.839	-0.310	<.001	<.001	3	4
BRCA	ASH1L →	-0.585	-0.296	.001	<.001	3	4
UCEC	GORAB →	-0.670	-0.468	<.001	.002	3	4
HNSC	MYPN →	+1.472	+0.336	<.001	.001	3	4
LSCC	POU2F1 →	-0.567	-0.321	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,881 associations by consensus.

MCU vs HEATR1 — BRCA

Explore this scatter interactively →