MCU

Across TCGA pan-cancer cohorts, MCU RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MCU’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MCU RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MCU is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRP, LIHC, and LUAD are the cancer types where MCU tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MCU RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+2.270	<.001	11	view →
LIHC	Female	II,III,IV	+1.255	<.001	9	view →
LUAD	Male	II,III,IV	+0.975	<.001	8	view →
COAD	All	All	−0.440	<.001	6	view →
STAD	Male	All	+0.936	.001	5	view →
THCA	All	All	+0.301	<.001	5	view →
KICH	Female	All	−0.712	<.001	4	view →
HNSC	All	III,IV	+0.574	.003	4	view →
BRCA	All	II,III,IV	+0.446	<.001	4	view →
CHOL	Female	All	+2.336	<.001	3	view →
ESCA	All	II,III,IV	+1.599	.018	3	view →
READ	All	All	−0.562	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MCU–KIRP

Open the KIRP breakdown →