MCOLN3

Across TCGA cell cohorts, MCOLN3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCOLN3-associated genes across cancer lineages are OR1L1, OR4A47, and ACTRT1. Each is linked with MCOLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCOLN3-to-partner and partner-to-MCOLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L1 grouped by MCOLN3-low versus MCOLN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN3→partner) and Y-score (partner→MCOLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR1L1 →	+0.039	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR4A47 →	+0.030	+6.022	<.001	.001	3	1
LUNG_NSCLC_LUAD	ACTRT1 →	+0.015	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L1 by MCOLN3 expression — LARGE_INTESTINE

Explore this box plot interactively →