MCOLN3

Across TCGA pan-cancer cohorts, MCOLN3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MCOLN3 data layer compared with 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MCOLN3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCOLN3 expression acts as an unfavorable survival marker, although some lineages such as PAAD and BRCA show a favorable association.

COAD, UCEC, and LGG are the cancer types where MCOLN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	IV	0.301	0.732	<.001	85	view →
UCEC	OS	Tertile	All	0.582	0.736	<.001	72	view →
LGG	OS	Median	All	0.753	0.857	<.001	39	view →
PAAD	DFS	Quartile	All	0.445	0.182	.001	39	view →
KIRP	DFS	Tertile	IV	0.054	1.000	.004	24	view →
BRCA	OS	Tertile	III,IV	0.938	0.847	.016	21	view →
STAD	OS	Quartile	III,IV	0.507	0.726	.019	16	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	15	view →
KIRC	OS	Tertile	All	0.861	0.768	.004	14	view →
OV	OS	Quartile	IV	0.605	0.352	.018	14	view →
THCA	DFS	Median	IV	0.482	0.924	.008	13	view →
UCS	OS	Tertile	IV	0.156	0.647	.047	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MCOLN3–COAD (DFS)

Open the COAD breakdown →