MCOLN1

Across TCGA patient cohorts, MCOLN1 RNA expression is significantly associated with the mutation status of many other genes, with 10,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCOLN1-associated genes across cancer lineages are DCHS2, SPTA1, and TP53. Each is linked with MCOLN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MCOLN1-to-partner and partner-to-MCOLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCHS2 grouped by MCOLN1-low versus MCOLN1-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCOLN1→partner) and Y-score (partner→MCOLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DCHS2 →	+1.540	+0.314	<.001	<.001	3	4
UCEC	SPTA1 →	+1.231	+0.322	<.001	<.001	3	4
BRCA	TP53 →	-0.831	-0.194	<.001	<.001	3	3
UCEC	CIC →	+2.039	+0.411	<.001	<.001	3	3
UCEC	PCDH7 →	+2.534	+0.415	<.001	.001	3	3
CESC	INSR →	+3.219	+0.458	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,574 associations by consensus.

DCHS2 by MCOLN1 expression — SKCM

Explore this box plot interactively →