MCOLN1

Across TCGA pan-cancer cohorts, MCOLN1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MCOLN1 data layer compared with 9 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MCOLN1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCOLN1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and CESC show a favorable association.

UVM, PAAD, and CESC are the cancer types where MCOLN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.388	0.751	<.001	69	view →
PAAD	DFS	Median	All	0.384	0.174	<.001	64	view →
CESC	DFS	Quartile	II,III,IV	0.914	0.636	.001	38	view →
KIRC	DFS	Quartile	All	0.768	0.471	<.001	36	view →
LGG	OS	Tertile	All	0.836	0.937	<.001	32	view →
LUSC	DFS	Tertile	III,IV	0.509	0.890	.001	30	view →
LAML	DFS	Quartile	All	0.269	0.580	.001	30	view →
SCLC	OS	Quartile	All	0.723	0.415	.008	15	view →
LIHC	DFS	Quartile	All	0.413	0.581	.002	15	view →
READ	OS	Quartile	All	0.672	0.929	.004	14	view →
SKCM	OS	Median	All	0.282	0.476	.002	13	view →
SARC	OS	Quartile	All	0.985	0.807	.005	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MCOLN1–UVM (DFS)

Open the UVM breakdown →