MCM8

Across TCGA patient cohorts, MCM8 protein abundance is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MCM8-associated genes across cancer lineages are FURIN, ABCA10, and NAA20. Each is linked with MCM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM8-to-partner and partner-to-MCM8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCM8 versus FURIN in BRCA, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM8→partner) and Y-score (partner→MCM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FURIN →	+0.230	+0.429	.009	.003	1	1
BRCA	ABCA10 →	-1.560	-0.435	.002	.003	1	1
BRCA	NAA20 →	+1.095	+0.580	.004	.007	1	1
BRCA	LSAMP →	-0.640	-0.435	.004	.003	1	1
BRCA	NLRP2 →	+4.289	+0.580	.009	.007	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MCM8 vs FURIN — BRCA

Explore this scatter interactively →