MCM8

Across TCGA pan-cancer cohorts, MCM8 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MCM8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MCM8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MCM8 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where MCM8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MCM8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.443	<.001	12	view →
BLCA	Female	All	+1.345	<.001	11	view →
COAD	Female	II,III,IV	+0.982	<.001	11	view →
STAD	Male	II,III,IV	+1.545	<.001	9	view →
LIHC	Female	II,III,IV	+1.344	<.001	9	view →
LUAD	Male	II,III,IV	+1.167	<.001	9	view →
LUSC	Male	II,III,IV	+2.056	<.001	8	view →
BRCA	All	III,IV	+0.726	<.001	8	view →
THCA	All	II,III,IV	−0.445	<.001	8	view →
UCEC	All	II,III,IV	+1.318	<.001	6	view →
KIRC	All	II,III,IV	−0.419	<.001	6	view →
CHOL	Male	All	+2.625	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MCM8–HNSC

Open the HNSC breakdown →