MCM4

Across TCGA patient cohorts, MCM4 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,778 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MCM4-associated proteins across cancer lineages are RIF1, RPL12_S38, and RRM1. Each is linked with MCM4 in more than 9 cancer types. Because this analysis shows association rather than direction, both MCM4-to-partner and partner-to-MCM4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCM4 versus RIF1 in LSCC, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM4→partner) and Y-score (partner→MCM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIF1 →	+0.460	+0.786	<.001	<.001	3	10
BRCA	RPL12_S38 →	+1.213	+0.716	<.001	<.001	3	10
LUAD	RRM1 →	+0.536	+1.284	<.001	<.001	3	10
LUAD	RRM2 →	+0.860	+1.118	<.001	<.001	3	10
GBM	SMC2 →	+0.771	+0.851	<.001	<.001	3	10
GBM	SMC4 →	+0.720	+0.852	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,778 associations by consensus.

MCM4 vs RIF1 — LSCC

Explore this scatter interactively →