MCM4

Across TCGA pan-cancer cohorts, MCM4 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MCM4 data layer compared with 4 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher MCM4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MCM4 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUSC show a favorable association.

MESO, ACC, and UVM are the cancer types where MCM4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.405	0.679	<.001	132	view →
ACC	DFS	Median	All	0.236	0.660	<.001	130	view →
UVM	DFS	Median	All	0.422	0.788	<.001	99	view →
KICH	DFS	Tertile	II,III,IV	0.440	0.937	.001	84	view →
LIHC	OS	Tertile	All	0.671	0.849	<.001	66	view →
LUAD	OS	Median	All	0.286	0.426	<.001	56	view →
KIRP	OS	Quartile	All	0.571	0.802	<.001	53	view →
PAAD	DFS	Quartile	All	0.152	0.441	<.001	49	view →
SARC	OS	Median	All	0.408	0.619	<.001	48	view →
LGG	OS	Median	All	0.736	0.893	<.001	47	view →
UCS	OS	Quartile	III,IV	0.595	0.231	.005	42	view →
UCEC	OS	Tertile	All	0.895	0.972	<.001	34	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MCM4–MESO (OS)

Open the MESO breakdown →