MCM4

Across TCGA patient cohorts, MCM4 mutation is significantly associated with the RNA expression of many other genes, with 2,241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM4-associated genes across cancer lineages are RN7SL248P, ZNHIT3, and CERS3-AS1. Each is linked with MCM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM4-to-partner and partner-to-MCM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by MCM4-low versus MCM4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM4→partner) and Y-score (partner→MCM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL248P →	+0.080	+4.786	<.001	.004	3	2
UCEC	ZNHIT3 →	+0.398	+2.080	<.001	<.001	3	2
SKCM	CERS3-AS1 →	+0.405	+2.589	<.001	.009	3	2
SKCM	NIFKP8 →	+0.127	+3.011	<.001	.002	3	2
SKCM	MIR4701 →	+0.969	+3.408	<.001	.007	3	2
UCEC	HAUS1 →	+0.399	+2.095	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,241 associations by consensus.

RN7SL248P by MCM4 expression — BRCA

Explore this box plot interactively →