MCM3AP

Across TCGA patient cohorts, MCM3AP mutation is significantly associated with the RNA expression of many other genes, with 6,128 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM3AP-associated genes across cancer lineages are ECHS1, C12orf57, and MRPS27. Each is linked with MCM3AP in more than 4 cancer types. Because this analysis shows association rather than direction, both MCM3AP-to-partner and partner-to-MCM3AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECHS1 grouped by MCM3AP-low versus MCM3AP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM3AP→partner) and Y-score (partner→MCM3AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ECHS1 →	+0.274	+2.255	.001	<.001	3	5
COAD	C12orf57 →	+0.741	+2.614	<.001	.005	3	4
UCEC	MRPS27 →	+0.373	+1.328	<.001	<.001	3	4
COAD	ADPRS →	+0.368	+2.362	.001	.003	3	4
UCEC	RPA2 →	+0.348	+1.837	<.001	<.001	3	4
UCEC	EMC4 →	+0.221	+1.579	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,128 associations by consensus.

ECHS1 by MCM3AP expression — UCEC

Explore this box plot interactively →