MCM3AP

Across TCGA pan-cancer cohorts, MCM3AP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MCM3AP’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MCM3AP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MCM3AP is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and HNSC are the cancer types where MCM3AP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MCM3AP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.183	<.001	8	view →
THCA	All	II,III,IV	−0.491	<.001	8	view →
HNSC	All	II,III,IV	+0.403	<.001	8	view →
STAD	Male	II,III,IV	+0.842	.004	6	view →
CHOL	Male	All	+1.614	<.001	5	view →
KICH	All	All	−0.611	<.001	4	view →
ESCA	All	II,III,IV	+0.380	.024	4	view →
KIRC	All	All	+0.333	<.001	3	view →
UCEC	All	All	−0.436	.025	2	view →
PRAD	All	All	+0.349	.002	2	view →
COAD	Male	All	+0.240	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MCM3AP–LIHC

Open the LIHC breakdown →