MCM3

Across TCGA patient cohorts, MCM3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM3-associated genes across cancer lineages are FoxM1, Notch1, and p62 Lck ligand. Each is linked with MCM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM3-to-partner and partner-to-MCM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MCM3-low versus MCM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM3→partner) and Y-score (partner→MCM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.290	+1.662	.001	.011	3	2
UCEC	Notch1 →	+0.200	+2.235	<.001	.005	3	2
UCEC	p62 Lck ligand →	+0.472	+2.874	<.001	<.001	3	2
UCEC	PCNA →	+0.323	+2.392	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.709	+1.604	<.001	.021	3	2
UCEC	14-3-3_beta →	-0.087	-1.973	.014	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

FoxM1 by MCM3 expression — UCEC

Explore this box plot interactively →