MCM3

Across TCGA cell cohorts, MCM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,572 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MCM3-associated GO terms across cancer lineages are DNA replication, Meiotic chromosome condensation, and DNA strand elongation involved in DNA replication. Each is linked with MCM3 in more than 18 cancer types. Because this analysis shows association rather than direction, both MCM3-to-partner and partner-to-MCM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by MCM3-low versus MCM3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM3→partner) and Y-score (partner→MCM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication →	+0.114	+1.134	<.001	<.001	3	19
OESOPHAGUS	Meiotic chromosome condensation →	+0.244	+1.033	.001	.003	3	19
BONE	DNA strand elongation involved in DNA replication →	+0.179	+1.326	.002	.001	3	19
BONE	Mitotic DNA replication checkpoint signaling →	+0.234	+1.814	<.001	<.001	3	19
BONE	DNA replication checkpoint signaling →	+0.250	+1.970	<.001	<.001	3	19
PANCREAS	Lagging strand elongation →	+0.380	+1.697	.006	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,572 associations by consensus.

DNA replication by MCM3 expression — BONE

Explore this box plot interactively →