MC4R

Across TCGA patient cohorts, MC4R mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MC4R-associated genes across cancer lineages are ATM, Rad50, and Caspase-7-cleavedD198. Each is linked with MC4R in more than 2 cancer types. Because this analysis shows association rather than direction, both MC4R-to-partner and partner-to-MC4R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MC4R-low versus MC4R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC4R→partner) and Y-score (partner→MC4R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.503	-2.321	.002	.001	3	3
UCEC	Rad50 →	-0.289	-2.321	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.658	+1.720	.002	.025	3	2
UCEC	Cyclin-D1 →	+0.158	+1.700	.006	.042	3	2
UCEC	EGFR_pY1068 →	-0.206	-1.925	.022	.005	3	1
UCEC	eIF4E →	+0.169	+2.335	.026	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by MC4R expression — UCEC

Explore this box plot interactively →