MC4R

Across TCGA pan-cancer cohorts, MC4R RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MC4R’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where MC4R RNA is repressed in tumor relative to normal tissue. In most cancer types MC4R is over-expressed in tumor, although a few such as STAD and KICH show the opposite, repressed pattern.

STAD, LUAD, and KICH are the cancer types where MC4R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MC4R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Female	III,IV	−0.339	<.001	7	view →
LUAD	All	All	+0.223	<.001	5	view →
KICH	All	All	−0.075	.004	5	view →
COAD	Female	II,III,IV	−0.107	.004	3	view →
KIRC	Female	II,III,IV	−0.071	.020	3	view →
LUSC	All	All	+0.287	.003	2	view →
READ	Female	All	−0.058	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MC4R–STAD

Open the STAD breakdown →