MC4R

Across TCGA pan-cancer cohorts, MC4R RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MC4R data layer compared with 7 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MC4R RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MC4R expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

BLCA, HNSC, and LUAD are the cancer types where MC4R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	IV	0.381	0.536	.006	53	view →
HNSC	OS	Quartile	III,IV	0.803	0.601	.001	44	view →
LUAD	OS	Median	All	0.734	0.627	.004	38	view →
LGG	DFS	Median	All	0.802	0.670	<.001	38	view →
ACC	OS	Quartile	II,III,IV	0.268	0.653	.005	33	view →
KIRC	OS	Median	All	0.549	0.677	.004	31	view →
SCLC	DFS	Tertile	II,III,IV	0.356	1.000	.006	16	view →
THCA	DFS	Tertile	III,IV	0.694	0.931	.001	16	view →
UCS	OS	Quartile	II,III,IV	0.771	0.323	.017	10	view →
KICH	DFS	Tertile	IV	0.269	0.784	.045	9	view →
THYM	DFS	Quartile	III,IV	0.457	1.000	.015	9	view →
SKCM	DFS	Tertile	All	0.271	0.161	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MC4R–BLCA (DFS)

Open the BLCA breakdown →