MC4R

Across TCGA cell cohorts, MC4R RNA expression is significantly associated with the go_rna of many other GO terms, with 863 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MC4R-associated GO terms across cancer lineages are Axoneme assembly, COPII-coated vesicle budding, and Aerobic respiration. Each is linked with MC4R in more than 5 cancer types. Because this analysis shows association rather than direction, both MC4R-to-partner and partner-to-MC4R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Axoneme assembly grouped by MC4R-low versus MC4R-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MC4R→partner) and Y-score (partner→MC4R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Axoneme assembly →	-0.034	-0.086	<.001	<.001	3	6
SKIN	COPII-coated vesicle budding →	+0.058	+0.090	.002	.001	3	6
LUNG_SCLC	Aerobic respiration →	+0.053	+0.652	.003	<.001	3	6
SOFT_TISSUE	Alternative mRNA splicing, via spliceosome →	+0.085	+0.241	<.001	<.001	2	6
SKIN	Establishment of mitotic spindle localization →	+0.068	+0.096	.001	.001	3	5
SOFT_TISSUE	Vesicle budding from membrane →	+0.052	+0.176	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 863 associations by consensus.

Axoneme assembly by MC4R expression — SKIN

Explore this box plot interactively →