MC4R

Across TCGA cell cohorts, MC4R mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MC4R-associated genes across cancer lineages are RESP18, NCBP2L, and TAS2R41. Each is linked with MC4R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC4R-to-partner and partner-to-MC4R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RESP18 grouped by MC4R-low versus MC4R-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC4R→partner) and Y-score (partner→MC4R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RESP18 →	+0.062	+5.169	<.001	.005	3	1
STOMACH	NCBP2L →	+0.109	+4.044	<.001	.003	3	1
STOMACH	TAS2R41 →	+0.054	+3.432	<.001	.008	3	1
STOMACH	FMO2 →	+0.278	+3.632	.002	.009	3	1
BLOOD_Leukemia	HIGD1C →	+0.091	+5.201	<.001	.006	3	1
LARGE_INTESTINE	KCTD8 →	+0.183	+4.095	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

RESP18 by MC4R expression — BREAST

Explore this box plot interactively →