MBD3L1

Across TCGA patient cohorts, MBD3L1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD3L1-associated genes across cancer lineages are FoxM1, TFRC, and Rab25. Each is linked with MBD3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD3L1-to-partner and partner-to-MBD3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MBD3L1-low versus MBD3L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD3L1→partner) and Y-score (partner→MBD3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.291	+3.169	.040	.020	3	2
SKCM	TFRC →	+0.768	+3.000	.007	.035	3	2
UCEC	Rab25 →	-0.633	-3.169	<.001	.020	3	1
UCEC	BRCA2 →	-0.148	-3.162	.033	.019	3	1
UCEC	4E-BP1 →	+0.392	+3.169	.008	.020	2	2
UCEC	C-Raf →	+0.255	+3.169	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by MBD3L1 expression — UCEC

Explore this box plot interactively →