MBD3L1

Across TCGA pan-cancer cohorts, MBD3L1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MBD3L1 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MBD3L1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MBD3L1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LIHC show a favorable association.

KIRC, ACC, and BRCA are the cancer types where MBD3L1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	III,IV	0.518	0.675	.007	94	view →
ACC	DFS	Tertile	All	0.304	0.629	.002	63	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
UCEC	OS	Quartile	All	0.969	0.908	.001	28	view →
LUAD	DFS	Tertile	IV	0.484	0.936	.001	24	view →
SKCM	OS	Tertile	III,IV	0.277	0.736	.001	24	view →
PCPG	OS	Tertile	All	0.892	0.985	.009	18	view →
LIHC	DFS	Tertile	All	0.923	0.493	.012	12	view →
MESO	OS	Tertile	III,IV	0.793	0.509	.030	9	view →
PAAD	DFS	Tertile	III,IV	0.152	0.821	.045	9	view →
UVM	DFS	Tertile	III,IV	0.129	0.673	.017	9	view →
CESC	DFS	Quartile	All	0.741	0.842	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

MBD3L1–KIRC (DFS)

Open the KIRC breakdown →