MBD2

Across TCGA cell cohorts, MBD2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MBD2-associated genes across cancer lineages are OR1L3, FAM47C, and PPP1R2C. Each is linked with MBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD2-to-partner and partner-to-MBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by MBD2-low versus MBD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD2→partner) and Y-score (partner→MBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	PPP1R2C →	+0.240	+4.539	<.001	.007	3	1
BLOOD_Leukemia	ADAM2 →	+0.144	+4.539	<.001	.007	3	1
BLOOD_Leukemia	LGALS13 →	+0.663	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SLC17A2 →	+0.011	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR1L3 by MBD2 expression — SKIN

Explore this box plot interactively →