MBD2

Across TCGA pan-cancer cohorts, MBD2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MBD2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MBD2 RNA is repressed in tumor relative to normal tissue. In most cancer types MBD2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where MBD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MBD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.614	<.001	11	view →
KIRC	Male	All	+0.470	<.001	11	view →
KICH	Female	II,III,IV	−1.564	<.001	8	view →
LIHC	All	II,III,IV	+0.678	<.001	8	view →
LUSC	Male	II,III,IV	+0.521	<.001	6	view →
CHOL	Female	All	+1.930	<.001	5	view →
COAD	All	All	−0.372	<.001	4	view →
HNSC	All	All	+0.302	.016	3	view →
PAAD	All	All	−0.569	.025	2	view →
LUAD	All	All	−0.154	.024	2	view →
BLCA	Male	IV	+0.642	.027	1	view →
READ	Female	All	−0.288	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MBD2–THCA

Open the THCA breakdown →