MAZ

Across TCGA patient cohorts, MAZ mutation is significantly associated with the RNA expression of many other genes, with 525 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAZ-associated genes across cancer lineages are CACTIN, NDUFC1, and CKS2. Each is linked with MAZ in more than 1 cancer types. Because this analysis shows association rather than direction, both MAZ-to-partner and partner-to-MAZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACTIN grouped by MAZ-low versus MAZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAZ→partner) and Y-score (partner→MAZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CACTIN →	+0.482	+3.818	<.001	<.001	3	2
UCEC	NDUFC1 →	+0.502	+3.501	.001	.002	3	2
UCEC	CKS2 →	+0.810	+3.346	<.001	.005	3	2
UCEC	ARRDC1 →	+0.477	+3.475	.004	.002	3	2
UCEC	MTATP6P21 →	+0.335	+2.774	<.001	<.001	3	2
BRCA	FAM8A2P →	+0.551	+3.646	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 525 associations by consensus.

CACTIN by MAZ expression — UCEC

Explore this box plot interactively →