MAZ

Across TCGA pan-cancer cohorts, MAZ RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MAZ’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAZ RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAZ is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where MAZ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAZ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.280	<.001	12	view →
KIRC	Female	All	+1.135	<.001	12	view →
KIRP	All	IV	+2.090	<.001	11	view →
LIHC	Female	II,III,IV	+1.687	<.001	9	view →
LUSC	Female	All	+1.344	<.001	8	view →
STAD	Male	II,III,IV	+1.256	<.001	8	view →
BLCA	All	All	+0.841	<.001	8	view →
LUAD	All	All	+0.441	<.001	8	view →
BRCA	All	III,IV	+1.104	<.001	6	view →
CHOL	Male	All	+2.386	<.001	5	view →
COAD	Female	All	+0.681	<.001	4	view →
PRAD	All	All	+0.653	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MAZ–HNSC

Open the HNSC breakdown →