MATN1

Across TCGA cell cohorts, MATN1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MATN1-associated genes across cancer lineages are KLK12, PRAMEF10, and PRAMEF17. Each is linked with MATN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MATN1-to-partner and partner-to-MATN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK12 grouped by MATN1-low versus MATN1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MATN1→partner) and Y-score (partner→MATN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLK12 →	+0.821	+4.930	<.001	.008	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LARGE_INTESTINE	SLC5A5 →	+0.336	+3.558	<.001	.006	3	1
LARGE_INTESTINE	MMP21 →	+0.044	+3.491	.001	.006	3	1
LARGE_INTESTINE	FMR1NB →	+0.197	+3.938	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

KLK12 by MATN1 expression — SOFT_TISSUE

Explore this box plot interactively →