MAST1

Across TCGA patient cohorts, MAST1 mutation is significantly associated with the RNA expression of many other genes, with 3,615 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAST1-associated genes across cancer lineages are SEC11C, TUBGCP5, and CISD2. Each is linked with MAST1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAST1-to-partner and partner-to-MAST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC11C grouped by MAST1-low versus MAST1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST1→partner) and Y-score (partner→MAST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SEC11C →	+0.510	+2.093	.007	.003	3	5
UCEC	TUBGCP5 →	+0.332	+1.754	.001	<.001	3	4
SKCM	CISD2 →	+0.445	+2.751	.001	.002	3	4
SKCM	GUF1 →	+0.523	+2.093	.001	.003	3	4
SKCM	BUB3 →	+0.395	+3.469	.006	.002	3	4
SKCM	SARS1 →	+0.446	+3.484	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,615 associations by consensus.

SEC11C by MAST1 expression — SKCM

Explore this box plot interactively →