MAST1

Across TCGA pan-cancer cohorts, MAST1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MAST1 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAST1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAST1 expression acts as an unfavorable survival marker, although some lineages such as LGG and HNSC show a favorable association.

KIRC, UCEC, and MESO are the cancer types where MAST1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.541	0.705	<.001	135	view →
UCEC	DFS	Median	All	0.558	0.750	<.001	78	view →
MESO	OS	Tertile	All	0.248	0.537	<.001	76	view →
LGG	DFS	Median	All	0.883	0.778	<.001	49	view →
HNSC	OS	Tertile	IV	0.779	0.607	.001	34	view →
READ	DFS	Tertile	IV	0.789	0.293	.004	27	view →
BLCA	DFS	Quartile	IV	0.167	0.627	<.001	21	view →
THCA	DFS	Tertile	IV	0.522	1.000	.007	17	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	14	view →
DLBC	DFS	Quartile	All	0.467	0.859	.014	12	view →
BRCA	DFS	Median	IV	0.336	0.731	.004	10	view →
PAAD	DFS	Tertile	All	0.485	0.258	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MAST1–KIRC (OS)

Open the KIRC breakdown →