MAST1

Across TCGA pan-cancer cohorts, MAST1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MAST1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MAST1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAST1 is over-expressed in tumor.

KIRP, LUAD, and HNSC are the cancer types where MAST1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAST1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.637	<.001	11	view →
LUAD	All	III,IV	+0.870	<.001	9	view →
HNSC	Male	III,IV	+0.705	<.001	8	view →
LUSC	Male	II,III,IV	+1.227	<.001	7	view →
BLCA	All	All	+1.138	.001	7	view →
UCEC	All	II,III,IV	+1.499	<.001	6	view →
LIHC	Male	All	+0.561	<.001	6	view →
BRCA	All	II,III,IV	+0.381	<.001	6	view →
THCA	All	All	+0.197	<.001	5	view →
COAD	All	III,IV	+0.416	.039	3	view →
KICH	All	II,III,IV	+0.479	.046	1	view →
KIRC	Male	All	+0.047	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MAST1–KIRP

Open the KIRP breakdown →