MAST1

Across TCGA cell cohorts, MAST1 mutation is significantly associated with the RNA expression of many other genes, with 1,886 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAST1-associated genes across cancer lineages are MMS22L, GKAP1, and C6orf136. Each is linked with MAST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAST1-to-partner and partner-to-MAST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMS22L grouped by MAST1-low versus MAST1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAST1→partner) and Y-score (partner→MAST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MMS22L →	+0.633	+2.714	.009	.002	3	3
BLOOD_Leukemia	GKAP1 →	+1.027	+3.730	<.001	<.001	3	3
LARGE_INTESTINE	C6orf136 →	+0.439	+2.714	.003	.002	3	3
BLOOD_Leukemia	FMR1 →	+0.575	+3.366	.003	.002	3	3
CNS	TACR3 →	+0.177	+3.000	<.001	.007	3	2
LARGE_INTESTINE	CCDC134 →	+0.592	+2.628	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,886 associations by consensus.

MMS22L by MAST1 expression — LARGE_INTESTINE

Explore this box plot interactively →