MARCKSL1

Across TCGA patient cohorts, MARCKSL1 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MARCKSL1-associated genes across cancer lineages are RNU4-13P, RNA5SP414, and RNU1-68P. Each is linked with MARCKSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCKSL1-to-partner and partner-to-MARCKSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-13P grouped by MARCKSL1-low versus MARCKSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCKSL1→partner) and Y-score (partner→MARCKSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-13P →	+0.168	+4.242	<.001	.006	3	2
UCEC	RNA5SP414 →	+0.669	+2.933	<.001	.006	3	1
UCEC	RNU1-68P →	+0.109	+4.069	<.001	.008	3	1
UCEC	RN7SL301P →	+0.204	+2.902	<.001	.006	3	1
UCEC	RNA5SP411 →	+1.409	+2.715	<.001	.006	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

RNU4-13P by MARCKSL1 expression — UCEC

Explore this box plot interactively →