MARCKSL1

Across TCGA pan-cancer cohorts, MARCKSL1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of MARCKSL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MARCKSL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MARCKSL1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where MARCKSL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MARCKSL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.051	<.001	11	view →
COAD	Male	III,IV	+1.320	<.001	11	view →
BLCA	All	III,IV	+2.113	<.001	10	view →
KIRC	Female	All	+1.122	<.001	10	view →
LUAD	Male	II,III,IV	+2.433	<.001	9	view →
STAD	Male	All	+2.735	<.001	8	view →
LUSC	Female	All	+2.355	<.001	8	view →
LIHC	Female	II,III,IV	+1.834	<.001	8	view →
BRCA	All	III,IV	+1.789	<.001	8	view →
UCEC	All	III,IV	+1.868	<.001	6	view →
ESCA	All	All	+2.221	.003	4	view →
CHOL	Male	All	+3.949	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

MARCKSL1–HNSC

Open the HNSC breakdown →