Across TCGA cell cohorts, MARCHF11 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MARCHF11-associated genes across cancer lineages are PRAMEF10, DIRC1, and ZAN. Each is linked with MARCHF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MARCHF11-to-partner and partner-to-MARCHF11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MARCHF11→partner) and Y-score (partner→MARCHF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	2
CNS	DIRC1 →	+0.096	+4.300	<.001	.001	3	1
LUNG_NSCLC_LUAD	ZAN →	+0.003	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPINK14 →	+0.211	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP2-1 →	+0.087	+3.866	.005	.006	3	1
BLOOD_Leukemia	REG3A →	+0.114	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

MARCHF11 survival (RNA) · tumor vs normal (RNA) · all MARCHF11 data types