MAPKAPK5

Across TCGA patient cohorts, MAPKAPK5 mutation is significantly associated with the RNA expression of many other genes, with 1,553 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPKAPK5-associated genes across cancer lineages are OR4G6P, FCGR1CP, and ASB16-AS1. Each is linked with MAPKAPK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPKAPK5-to-partner and partner-to-MAPKAPK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4G6P grouped by MAPKAPK5-low versus MAPKAPK5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAPK5→partner) and Y-score (partner→MAPKAPK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR4G6P →	+0.044	+7.640	<.001	.009	3	2
UCEC	FCGR1CP →	+0.416	+2.447	.001	.001	3	1
UCEC	ASB16-AS1 →	+0.470	+3.470	.001	.002	3	1
UCEC	CIRBP-AS1 →	+0.709	+3.616	<.001	.001	3	1
UCEC	ZNF887P →	+0.419	+1.928	.002	.009	3	1
UCEC	IGHV3-30 →	+1.681	+3.332	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,553 associations by consensus.

OR4G6P by MAPKAPK5 expression — BLCA

Explore this box plot interactively →