MAPKAPK5

Across TCGA pan-cancer cohorts, MAPKAPK5 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MAPKAPK5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAPKAPK5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAPKAPK5 is over-expressed in tumor.

COAD, BLCA, and LIHC are the cancer types where MAPKAPK5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAPKAPK5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+0.617	<.001	10	view →
BLCA	Female	III,IV	+0.588	<.001	10	view →
LIHC	Male	All	+0.835	<.001	9	view →
STAD	All	II,III,IV	+0.725	<.001	8	view →
HNSC	Male	III,IV	+0.567	<.001	8	view →
KIRC	All	All	+0.178	<.001	7	view →
BRCA	All	II,III,IV	+0.244	<.001	6	view →
CHOL	Male	All	+1.861	<.001	5	view →
LUSC	Male	II,III,IV	+0.444	<.001	5	view →
LUAD	Male	All	+0.338	.002	4	view →
KIRP	All	All	+0.256	.024	3	view →
READ	Female	All	+0.760	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MAPKAPK5–COAD

Open the COAD breakdown →