MAPK9

Across TCGA patient cohorts, MAPK9 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK9-associated genes across cancer lineages are p62 Lck ligand, PCNA, and eEF2. Each is linked with MAPK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK9-to-partner and partner-to-MAPK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by MAPK9-low versus MAPK9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK9→partner) and Y-score (partner→MAPK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.338	+3.710	.005	<.001	3	2
UCEC	PCNA →	+0.179	+2.222	.027	.010	3	2
UCEC	eEF2 →	+0.416	+2.169	.001	.003	3	1
UCEC	EGFR_pY1068 →	-0.315	-2.662	<.001	<.001	3	1
UCEC	eIF4E →	+0.159	+2.169	.045	.003	3	1
UCEC	A-Raf_pS299 →	-0.154	-1.765	<.001	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

p62 Lck ligand by MAPK9 expression — UCEC

Explore this box plot interactively →