MAPK9

Across TCGA pan-cancer cohorts, MAPK9 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MAPK9 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAPK9 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MAPK9 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, HNSC, and SKCM are the cancer types where MAPK9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.719	0.541	<.001	98	view →
HNSC	OS	Median	All	0.457	0.724	<.001	90	view →
SKCM	OS	Median	All	0.825	0.734	.001	80	view →
CESC	DFS	Tertile	All	0.750	0.878	.001	64	view →
READ	DFS	Quartile	All	0.724	0.280	.003	53	view →
LGG	OS	Median	All	0.929	0.861	<.001	39	view →
KIRP	OS	Median	All	0.909	0.978	.003	38	view →
LIHC	DFS	Tertile	All	0.460	0.640	<.001	34	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	33	view →
COAD	OS	Median	II,III,IV	0.886	0.673	<.001	30	view →
ACC	OS	Median	II,III,IV	0.946	0.755	.001	28	view →
KICH	OS	Tertile	II,III,IV	0.913	1.000	.023	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MAPK9–KIRC (OS)

Open the KIRC breakdown →