MAPK9

Across TCGA pan-cancer cohorts, MAPK9 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MAPK9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAPK9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAPK9 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where MAPK9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAPK9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.455	<.001	11	view →
LIHC	Female	II,III,IV	+1.030	<.001	9	view →
HNSC	All	II,III,IV	+0.382	<.001	9	view →
BRCA	All	III,IV	+0.656	<.001	8	view →
KIRP	All	II,III,IV	+0.391	.003	6	view →
LUSC	Male	All	−0.373	<.001	4	view →
LUAD	All	All	+0.163	.005	4	view →
CHOL	All	All	+1.658	<.001	3	view →
THCA	All	All	−0.199	.009	3	view →
STAD	All	II,III,IV	+0.408	.017	2	view →
UCEC	All	IV	−0.320	.033	2	view →
KICH	All	All	−0.367	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MAPK9–KIRC

Open the KIRC breakdown →