MAPK9

Across TCGA cell cohorts, MAPK9 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAPK9-associated genes across cancer lineages are MYOD1, MMP27, and KRTAP12-3. Each is linked with MAPK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK9-to-partner and partner-to-MAPK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by MAPK9-low versus MAPK9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK9→partner) and Y-score (partner→MAPK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.082	+5.539	<.001	.003	3	1
LARGE_INTESTINE	TTLL8 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PPEF2 →	+0.032	+3.736	.009	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MYOD1 by MAPK9 expression — BLOOD_Leukemia

Explore this box plot interactively →